四川中医

目的 研究蒙药僧登消肿药贴经皮给药的止痛抗炎作用。方法 随机将实验动物（小鼠、大鼠）分成空白对照组、模型对照组、阳性药物对照组、僧登消肿药贴低剂量组、中剂量组、高剂量组，分别建立机械刺激致大鼠足部压痛模型、醋酸致小鼠扭体反应模型、二甲苯致小鼠耳肿胀模型、醋酸致小鼠腹腔通透性增加模型、角叉菜胶致大鼠足肿胀模型、棉球致小鼠肉芽肿增生模型，测定痛阈值、扭体次数、耳肿胀抑制率、毛细血管通透性、棉球肉芽肿增生、足肿胀度等指标，评价僧登消肿药贴低、中、高剂量的止痛抗炎作用。结果 僧登消肿药贴中剂量与给药前痛阈值比较，中剂量组大鼠的痛阈值在第120min明显升高（P<0.05）；与模型对照组相比，僧登消肿药贴低剂量组小鼠以及僧登消肿药贴中剂量组雄性小鼠扭体潜伏时间均明显延长（P<0.05或P<0.01），僧登消肿药贴各剂量组小鼠扭体次数均明显减少（P<0.05或P<0.01），僧登消肿药贴各剂量组小鼠耳肿胀度均明显降低（P<0.01），僧登消肿药贴中剂量组吸光度值明显降低（P<0.05），僧登消肿药贴浸膏中剂量组大鼠第2h、4h、6h足肿胀度均明显减小（P<0.01或P<0.05），僧登消肿药贴高剂量组小鼠肉芽肿明显降低（P<0.01）。结论 蒙药僧登消肿药贴对物理和化学刺激具有一定的止痛作用，亦对急慢性炎性刺激有一定的抗炎作用。

Objective To investigate the analgesic and anti-inflammatory effects of Mongolian medicine Sengdeng Anti swelling patch administered via transdermal delivery. Methods Experimental animals(mice and rats) were randomly divided into a blank control group, a model control group, a positive drug control group, and low-, medium-, and high-dose groups of Mongolian medicine Sengdeng Anti swelling patch. These following models were established: A mechanical stimulation-induced foot plantar hyperalgesia model in rats, an acetic acid-induced writhing response model in mice, a xylene-induced ear swelling model in mice, an acetic acid-induced increased peritoneal permeability model in mice, a carrageenan-induced foot swelling model in rats, and a cotton pellet-induced granuloma hyperplasia model in mice. Pain thresholds, writhing counts, ear swelling inhibition rates, capillary permeability, cotton pellet granuloma hyperplasia, and foot swelling degrees were measured to evaluate the analgesic and anti-inflammatory effects of Mongolian medicine Sengdeng Anti swelling patch at low, medium, and high doses. Results Compared with the pain threshold before administration, the pain threshold of rats in the medium-dose group of Mongolian medicine Sengdeng Anti swelling patch significantly increased at 120 min(P<0.05). Compared with the model control group, the latency time of writhing in the low-dose group of Mongolian medicine Sengdeng Anti swelling patch and the male mice in the medium-dose group was significantly prolonged(P<0.05 or P<0.01). The number of writhing episodes in all dose groups of Mongolian medicine Sengdeng Anti swelling patch significantly decreased(P<0.05 or P<0.01), and the ear swelling degree in all dose groups significantly reduced(P<0.01). The absorbance value in the medium-dose group of Mongolian medicine Sengdeng Anti swelling patch significantly decreased(P<0.05). In the medium-dose group of Mongolian medicine Sengdeng Anti swelling patch extract, the foot swelling degree at 2h, 4h, and 6h significantly decreased(P<0.01 or P<0.05). The granuloma formation in the high-dose group of Mongolian medicine Sengdeng Anti swelling patch significantly decreased(P<0.01). Conclusion Mongolian medicine Sengdeng Anti swelling patch has a certain analgesic effect on physical and chemical stimuli, and also has a certain anti-inflammatory effect on acute and chronic inflammatory stimuli.